Therapeutic Modalities
Small molecules
Small molecules
Small molecules
Typically these are chemicals with molecular weight <1000 g/mol.
Peptides
Small molecules
Small molecules
Natural or chemically modified peptides of any length.
Degraders
Small molecules
Antibodies
These are chimeric chemicals with molecular weight <1500 g/mol.
Antibodies
Small molecules
Antibodies
Fully assembled antibodies or its components (Fab, Fc).
Examples: TRANSCRIPTION FACTORS
cMYC
BCL9
BCL9
- Target family: HLH, Leuzine zipper
- Length: 454 aa
- Engagement confidence: Moderate
CHD4
BCL9
TEAD4
- Target family: Zinc finger, disordered
- Length: 1912 aa
- Engagement confidence: High
TEAD4
TEAD4
TEAD4
- Target family: Disordered
- Length: 434 aa
- Engagement confidence: Moderate
TBL1X
TEAD4
TBL1X
- Target family: WD, Disordered
- Length: 577 aa
- Engagement confidence: High
Examples: Enzymes
MTH1
KRAS
KRAS
- Target family: Nudix hydrolase
- Length: 156 aa
- Engagement confidence: High
DHFR
KRAS
PDE10
- Target family: Dihydrofolate reductase
- Length: 187 aa
- Engagement confidence: High
PLK1
PDE10
UBE2N
- Target family: POLO vox, Kinase
- Length: 603 aa
- Engagement confidence: High
UBE2N
PDE10
UBE2N
- Target family: Ubiquitin conjugator
- Length: 152 aa
- Engagement confidence: High
Examples: Membrane proteins
EGFR
C5aR1
EGFR
- Target family: Kinase, Disordered
- Length: 1210 aa
- Engagement confidence: High
B2AR
C5aR1
EGFR
- Target family: PDZ binder, Disordered
- Length: 413 aa
- Engagement confidence: High
C5aR1
C5aR1
C5aR1
- Target family: G protein receptor
- Length: 350 aa
- Engagement confidence: High
MCT4
GRP75
C5aR1
- Target family: Monocarboxylate porter
- Length: 465 aa
- Engagement confidence: High
Examples: Other Targets
SKP2
KDM3A
SKP2
- Target family: Leucine-rich repeat
- Length: 424 aa
- Engagement confidence: Moderate
P27
KDM3A
SKP2
- Target family: Cyclin-dependent kinase
- Length: 198 aa
- Engagement confidence: Moderate
KDM3A
KDM3A
KDM3A
- Target family: Zinc finger, LXXLL
- Length: 1321
- Engagement confidence: High