MICRO-TAG® Cellular Target Engagement
POWERING DRUG DISCOVERY WITH REAGENTS AND SOLUTIONS
MICRO-TAG® Cellular Target Engagement
POWERING DRUG DISCOVERY WITH REAGENTS AND SOLUTIONS
What is MICRO-TAG® technology?
Cellular Context
Quantitative Readouts
Quantitative Readouts
Cellular Target Engagement in Native Context
Directly quantitates ligand–target engagement inside intact cells, preserving native protein context and cellular environment.
Quantitative Readouts
Quantitative Readouts
Quantitative Readouts
Real-Time & Multi-Layered Data for Deep Analysis
Real-time & temperature-series measurements generate quantitative readouts, enabling layered comparison across compounds and targets.
Lab-Ready Workflow
Quantitative Readouts
Lab-Ready Workflow
Designed for Standard Lab Infrastructure
Compatible with standard real-time qPCR systems for fluorescence detection, requiring no specialized instrumentation.
Proven Target Engagement Technology
MICRO-TAG® is based on a novel enzyme complementation chemistry that converts cellular target engagement into a measurable fluorescent signal.
The technology was developed and validated on 100+ drug targets, spanning hit discovery, hit validation and mechanistic analyses, before being standardized into reagent kits.
Micro-tag® REAGENTS
MICRO-TAG® Real-Time Cellular Target Engagement Kit
MICRO-TAG® Real-Time Cellular Target Engagement Kit
MICRO-TAG® Real-Time Cellular Target Engagement Kit
Time-resolved measurements that capture target engagement dynamics and mechanism.
MICRO-TAG® Cellular DNA Encoded Library (DEL) Kit
MICRO-TAG® Real-Time Cellular Target Engagement Kit
MICRO-TAG® Real-Time Cellular Target Engagement Kit
DEL discovery of novel therapeutic candidates engaging with target under cellular conditions.
MICRO-TAG® Protein Complex Target Engagement Kit
MICRO-TAG® Real-Time Cellular Target Engagement Kit
MICRO-TAG® Protein Complex Target Engagement Kit
Time-resolved measurements of engagement with protein complexes with functional readout.
Designed for Challenging Discovery Questions
Challenging Drug Targets & Modalities
Cellular Discovery with DNA-Encoded Libraries
Cellular Discovery with DNA-Encoded Libraries
Specifically applicable to transcription factors, GPCRs, protein complexes, difficult enzymatic targets & other target classes.
Cellular Discovery with DNA-Encoded Libraries
Cellular Discovery with DNA-Encoded Libraries
Cellular Discovery with DNA-Encoded Libraries
Enabling DEL (DNA-Encoded Library) discovery under cellular conditions for de novo discovery of physiologically relevant target binders.
Multiple Therapeutic Modalities
Cellular Discovery with DNA-Encoded Libraries
Multiple Therapeutic Modalities
Applicable across conventional small-molecule modalities, active site & allosteric binders, glues, degraders, covalent inhibitors and peptides.
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