MICRO-TAG: A Novel Fluorescence-Based Real-Time Cellular Target Engagement Platform for Drug Discovery
MICRO-TAG A Novel Flurescence-Based Real-Time Cellular Target Engagement Platform for Drug Discovery (pdf)
DownloadHere we bring together the two major elements in early drug discovery: Target engagement in silico & Target engagement in cell.
Eric Sigel, CEO @ Citadel Discovery, we will dissect the fundamentals of predictive drug discovery and DEL / ML to fuel therapeutic pipelines focused on challenging drug targets. Ivan Babic, Cofounder @ CellarisBio, will dissect the importance of pairing predictive drug discovery with live cell systems.
This webinar provides insight into practices of target discovery & validation together with importance of target engagement in designing winning drug discovery programs. Starred by Dr Christopher Miller, ex-head genomics research center at Abbvie and ex-VP of functional genomics at GSK, we dissect the success of target discovery and validation through functional genomics. Dr Miller also ties into the importance of target engagement early in drug discovery.
In this webinar we review the discovery of potent pan-KRAS inhibitors for gastrointestinal and pancreatic cancers. Led by legendary Professor Gary A. Piazza of Auburn University, the story will delve into layers of target biology, mechanism of action of the novel KRAS inhibitors, together with the preclinical data.
The webinar will review the fundamentals of cell target engagement and its importance in early drug discovery. It provides a short comparative synopsis of conventional biophysical methods (such as SPR, MST, DSF etc) that require purified and well structured and functional recombinant proteins. It also provides a review of cell target engagement methods together with enzyme complementation technologies.
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