MICRO-TAG® reagents enable discovery teams to perform quantitative cellular target engagement assays directly in their own laboratories. The reagent portfolio supports multiple measurement modes and discovery workflows while preserving a consistent underlying technology and data structure.
Measure ligand–target engagement directly in intact cells or lysates, preserving native protein folding and cellular environment.
Generate standardized metrics that allow reliable comparison across compounds, targets, and experimental campaigns.
Apply the same reagent framework across exploratory studies, hit validation and more advanced discovery workflows.

For kinetic and time-resolved measurements. Extends the MICRO-TAG® workflow to real-time readouts, enabling analysis of engagement dynamics, residence effects, and mechanistic differences between compounds.
Best suited for discovery and validation-stage programs requiring kinetic insight or deeper mechanistic insight for target engagement. Eg: allosteric binders.

For discovery of hits engaging with target under cellular conditions. Supports on-target hit discovery using potentially any DNA-encoded library (DEL) directly in cellular context, with real-time and mechanistically resolved readouts.
Best suited for programs focused on challenging drug targets that are not tractable with conventional purified protein-based DEL protocols. Eg: transcription factors.

For kinetic and time-resolved measurements of protein complex targets. Extends the MICRO-TAG® workflow to real-time readouts, enabling analysis of engagement dynamics, functional readout and ternary complex formation.
Best suited for discovery and validation-stage programs requiring mechanistic and functional insight into target protein complex formation. Eg: molecular glues.
MICRO-TAG® reagents are compatible with a growing catalog of 100+ validated targets spanning multiple target classes. Targets are ordered separately from reagent kits.
Catalytic proteins that drive biochemical reactions, including kinases, proteases, epigenetic enzymes, and metabolic enzymes.
Regulatory proteins that control gene expression through DNA binding, co-factor recruitment, and participation transcriptional complexes.
Integral or peripheral membrane-associated proteins, including receptors, transporters, and signaling adaptors.
Multi-protein assemblies involved in signaling, transcriptional regulation, chromatin remodeling, and scaffolding functions.
MICRO-TAG® reagents are available for research use through direct inquiry. Pricing, availability, and configuration can be discussed based on your experimental needs.
CellarisBio
San Diego, California, USA
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