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MICRO-TAG® CELL TARGET ENGAGEMENT REAGENTS

MICRO-TAG® reagents enable discovery teams to perform quantitative cellular target engagement assays directly in their own laboratories. The reagent portfolio supports multiple measurement modes and discovery workflows while preserving a consistent underlying technology and data structure.

What MICRO-TAG® Reagents Enable

Cellular Context

Scalable Assay Design

Quantitative Rigor

Measure ligand–target engagement directly in intact cells or lysates, preserving native protein folding and cellular environment.

Quantitative Rigor

Scalable Assay Design

Quantitative Rigor

Generate standardized metrics that allow reliable comparison across compounds, targets, and experimental campaigns.

Scalable Assay Design

Scalable Assay Design

Scalable Assay Design

Apply the same reagent framework across exploratory studies, hit validation and more advanced discovery workflows.

Micro-tag™ REAGENT KITS

MICRO-TAG® Real-Time Cellular Target Engagement Kit

For kinetic and time-resolved measurements. Extends the MICRO-TAG® workflow to real-time readouts, enabling analysis of engagement dynamics, residence effects, and mechanistic differences between compounds.


Best suited for discovery and validation-stage programs requiring kinetic insight or deeper mechanistic insight for target engagement. Eg: allosteric binders.

View Kit Details

MICRO-TAG® Cellular DNA Encoded Library (DEL) Kit

For discovery of hits engaging with target under cellular conditions. Supports on-target hit discovery using potentially any DNA-encoded library (DEL) directly in cellular context, with real-time and mechanistically resolved readouts. 


Best suited for programs focused on challenging drug targets that are not tractable with conventional purified protein-based DEL protocols. Eg: transcription factors.

View Kit Details

MICRO-TAG® Protein Complex Target Engagement Kit

For kinetic and time-resolved measurements of protein complex targets. Extends the MICRO-TAG® workflow to real-time readouts, enabling analysis of engagement dynamics,  functional readout and ternary complex formation. 


Best suited for discovery and validation-stage programs  requiring mechanistic and functional insight into target protein complex formation. Eg: molecular glues. 

View Kit Details

TARGET COMPATIBILITY

MICRO-TAG® reagents are compatible with a growing catalog of 100+ validated targets spanning multiple target classes. Targets are ordered separately from reagent kits.

Enzymes

Transcription factors

Transcription factors

Catalytic proteins that drive biochemical reactions, including kinases, proteases, epigenetic enzymes, and metabolic enzymes.


Transcription factors

Transcription factors

Transcription factors

Regulatory proteins that control gene expression through DNA binding, co-factor recruitment, and participation transcriptional complexes.

Membrane Proteins

Membrane Proteins

Membrane Proteins

Integral or peripheral membrane-associated proteins, including receptors, transporters, and signaling adaptors.

Protein Complexes

Membrane Proteins

Membrane Proteins

Multi-protein assemblies involved in signaling, transcriptional regulation, chromatin remodeling, and scaffolding functions.

See Validated Targets

Ordering & Access

MICRO-TAG® reagents are available for research use through direct inquiry. Pricing, availability, and configuration can be discussed based on your experimental needs.

Inquire about kits

MICRO-TAG® reagents provide a standardized and quantitative foundation for evaluating cellular target engagement across modern discovery workflows.

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